Non-shivering thermogenesis : uncoupling of oxidative phosphorylation

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Which of the following occurs in non-shivering thermogenesis? A) Glucose is oxidized to lactate B) Fatty acids uncouple oxidative phosphorylation C) ATP is spent on heat production D) Glycogen is excessively degraded E) Fatty acids are excessively oxidized The correct answer is C- Fatty acids uncouple oxidative phosphorylation Basic Concept The reduction of molecular oxygen […]

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Biological oxidation and Electron Transport Chain (Mcqs) – part-2

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1. Dehydrogenases catalyze the transfer of hydrogen from one substrate to another in a coupled oxidation-reduction reaction.These dehydrogenases are specific for their substrates but often utilize common coenzymes or hydrogen carriers, e.g. NAD+. Which out of the following is not niacin ( NAD+) dependent dehydrogenase? a) Pyruvate dehydrogenase b) Glycerol-3-P dehydrogenase( Mitochondrial ) c) Glyceraldehyde-3-P

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Biological oxidation and Electron transport chain (Multiple choice questions) – solved- part-3

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Q.1- Choose a site along the electron transport chain out of the following that is not coupled to ATP synthesis: a) NADH- coenzyme Q (CoQ) reductase b) Succinate-Co Q reductase c) Cytochrome bc1 reductase d) Cytochrome oxidase e) None of the above. Q.2- Choose a statement out of the following that best describes the uncouplers

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Electron transport chain and oxidative phosphorylation- Mcqs (set-1)

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Q.1- All of the following except one are NAD+ requiring enzymes – A. Acyl co A dehydrogenase B. Glyceraldehyde-3-P dehydrogenase C. Pyruvate dehydrogenase complex D. Malate dehydrogenase E. Lactate dehydrogenase Q.2- Which one of the following enzymes catalyzes substrate-level phosphorylation in the TCA cycle A. Malate dehydrogenase B. Succinate Thiokinase C. Succinate dehydrogenase D. Alpha

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Electron transport chain and oxidative phosphorylation- MCQs (Set-2)

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Q.1- If the mitochondria were blocked at the site of NADH oxidation and were treated with succinate as substrate, what would the P: O ratio is? A. Zero B. One less than normally produced by succinate C. Same as that normally produced by succinate D. One more than normally produced by succinate E. Higher than

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Electron Transport Chain – An Overview

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An 18-year-old college student is brought to the emergency room unconscious, with a very high serum alcohol level. Alcohol metabolism can result in high NADH levels. When NADH enters the electron transport chain, which of the following is the correct order in which electron transfer occurs? a) NADH, coenzyme Q, cytochrome c, FMN, O2 b)

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Impaired electron flow through complex II

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A -8-year-old boy is seen by an ophthalmologist for difficulties in seeing in all visual fields as well as slow eye movements. The ophthalmologist finds pigmentary retinopathy and ophthalmoplegia. The child is suspected to have Kearns- Sayre syndrome, a disorder due to a mutation in complex II of ETC. The electron transport from which substance

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Electron transport chain inhibition by Rotenone

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An unskilled worker in a water garden was sent to sweep up a spill of white powder in the storage shed. Later, he was found with labored breathing and convulsions. On further examination, the white powder was identified as rotenone. Respiratory distress is induced by rotenone exposure because it inhibits the complex that catalyzes which

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