General Introduction Carbohydrates are the most abundant compounds found in nature (cellulose: 100 billion tons annually) They make up most of the organic matter on earth because of their extensive roles in all forms of life. One of the four major classes of biomolecules along with proteins, nucleic acids, and lipids. The term carbohydrate is derived […]
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1-Describe the role of tumor suppressor genes in human carcinogenesis. 2- List, giving an example for each, the ways by which proto-oncogenes can be converted to oncogenes. 3- Chromosomal translocations are the hallmark of certain human malignancies. What is known of the biochemical consequences of these cytogenic rearrangements and how these contribute to the development
Frequently asked long and short answer questions-cancers Read More »
Q.1- Enzymes of which type are responsible for converting Pro carcinogens to Ultimate carcinogens? a) Cytochrome P 450 enzyme system b) Hydrolase c) Transferases d) Acetylases e) Polyamine oxidases Q.2- Which of the following is the most commonly mutated oncogene in cancer? a) p53 b) abl c) ras d) myc e) BRCA Q.3- A 23-year-old woman is
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“International Union Against cancer” has defined Cancer as a disturbance of growth, characterized by excessive proliferation of cells without apparent relation to the physiological demands of the organ involved. Properties of cancer cells Three important properties- 1) Diminished or unrestricted control of growth 2) The capability of invasion of local tissues 3) Capable of spreading
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Cancer susceptibility genes There are two major classes of cancer susceptibility genes. A) Genes affecting cell growth- These genes exert their effects on tumor growth through their ability to control cell division (cell birth) or cell death (apoptosis).There are two types of genes affecting cell growth. Tumor suppressor genes– negatively affect cell growth. The normal
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Oncogenes in Human Cancer Oncogenes are cancer susceptibility genes. Proto-oncogenes are normal genes that are present in normal cells and are involved in normal growth and development. Under certain circumstances due to the effect of certain processes protooncogenes are converted to Oncogenes. Significance of Proto-oncogenes In the normal cellular environment, proto-oncogenes have crucial roles in
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Anticancer drugs The goal of cancer treatment is first to eradicate cancer. If this primary goal cannot be accomplished, the goal of cancer treatment shifts to palliation, the amelioration of symptoms, and preservation of quality of life while striving to extend life. Cancer treatments are divided into four main types: surgery, radiation therapy (including photodynamic
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Tumor markers Tumor markers are hormones, enzymes, peptides or proteins abnormally synthesized and released by the cancer cells, or are produced by the host cells in response to cancerous growth. Tumor markers may be present in the body fluids, blood, cell membranes or in the cytoplasm of the cell. Clinical significance of tumor markers Tumor
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Methotrexate Methotrexate is an antimetabolite. A broad definition of antimetabolites would include compounds with structural similarity to precursors of purines or pyrimidines or compounds that interfere with purine or pyrimidine synthesis. Antimetabolites can cause DNA damage indirectly, through misincorporation into DNA, abnormal timing or progression through DNA synthesis, or altered function of pyrimidine and purine
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Biological oxidation and oxidative phosphorylation from Namrata Chhabra
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