and oxidative phosphorylation
11. A 48-year-old patient is brought to the emergency room after exposure to toxic fumes suspected to contain cyanide. He presents with shortness of breath, confusion, and metabolic acidosis. The medical team suspects cyanide toxicity, which disrupts the electron transport chain (ETC). Which of the following statements concerning the components of the electron transport chain […]
1. A 60-year-old man is admitted to the hospital with confusion, fatigue, and muscle weakness. His symptoms suggest mitochondrial dysfunction, potentially caused by exposure to a toxin that inhibits the electron transport chain. Laboratory tests reveal a disruption in ATP production, and the medical team suspects inhibition at Complex I. Which of the following is
Site of Action Inhibitors / Uncouplers Mechanism Mnemonic for Easy Recall Complex I (NADH Dehydrogenase) Rotenone, Piericidin A, Amytal Blocks electron transfer from NADH to CoQ “Rotten Pies Available” (Rotenone, Piericidin A, Amytal block Complex I) Complex II (Succinate Dehydrogenase) Malonate, Carboxin, TTFA Competes with succinate, preventing electron transfer to CoQ “Malonate Causes Trouble Fast”
ETC Inhibitors, Uncouplers, and Transporter Inhibitors of Oxidative Phosphorylation Read More »
Q.- Adenosine triphosphate (ATP) is the energy currency within the cell. Which of the following best describes the type of compound ATP is? A. Phospholipid B. Amino acid C. Nucleotide D. Triacylglycerol E. Oligosaccharide. Details The correct answer is -C- Nucleotide. The nucleotide coenzyme adenosine triphosphate (ATP) is the most important form of chemical energy
ATP- The energy currency within the cell Read More »
Biological oxidation and oxidative phosphorylation from Namrata Chhabra
Biological oxidation & Electron transport chain Read More »
Case Study A 30 -year- old patient reported to medical OPD complaining of generalized weakness, excessive perspiration, and high caloric intake without an increase in body weight. From the age of seven, she had suffered from profuse sweating that forced her to change clothes about ten times a day. To compensate for the loss of
Case study- Luft syndrome (Hypermetabolic mitochondrial syndrome) Read More »
Introduction Most of the energy liberated during the oxidation of carbohydrates, fatty acids, and amino acids are made available within mitochondria as reducing equivalents (—H or electrons). The NADH and FADH2 formed in glycolysis, fatty acid oxidation, and the citric acid cycle are energy-rich molecules because each contains a pair of electrons having a high
Electron Transport Chain -strictly aerobic (a brief review) Read More »
Under aerobic conditions regeneration of cytosolic NAD+ from cytosolic NADH is accomplished by transferring electrons across the mitochondrial membrane barrier to the electron transport chain where the electrons are transferred to oxygen. There are two different shuttle mechanisms whereby this transfer of electrons across the membrane to regenerate cytosolic NAD+ can be accomplished, the glycerol 3-phosphate shuttle and the malate-aspartate
Which of the following occurs in non-shivering thermogenesis? A) Glucose is oxidized to lactate B) Fatty acids uncouple oxidative phosphorylation C) ATP is spent on heat production D) Glycogen is excessively degraded E) Fatty acids are excessively oxidized The correct answer is C- Fatty acids uncouple oxidative phosphorylation Basic Concept The reduction of molecular oxygen
Non-shivering thermogenesis : uncoupling of oxidative phosphorylation Read More »
