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Transportation of Acetyl CoA

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Fatty acids are synthesized in the cytosol, whereas acetyl CoA is formed from pyruvate in mitochondria. Hence, acetyl CoA must be transferred from mitochondria to the cytosol. Mitochondria, however, are not readily permeable to acetyl CoA. Carnitine carries only long-chain fatty acids. The barrier to acetyl CoA is bypassed by citrate, which carries acetyl groups […]

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Fatty acid synthesis versus fatty acid oxidation

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“Although chemical processes involved are the same, Fatty acid synthesis is not simply a reversal of fatty acid oxidation.”              Fatty acid synthesis seems simply a reversal of the degradative pathway, but it consists of a new set of reactions, exemplifying the principle that synthetic and degradative pathways are almost

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