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Chemistry of Nucleotides-Multiple-choice questions

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1- Which statement best describes Xanthine ? a) It is a direct precursor of Guanine b) It covalently binds to Allopurinol c) It is oxidized to form Uric acid d) It is oxidized to form Hypoxanthine e) It is a substrate rather than a product of the enzyme Xanthine oxidase 2- Methylated heterocyclic bases of

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Structure, sources and functions of ATP

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ATP- Energy Currency of cell The nucleotide coenzyme adenosine triphosphate (ATP) is the most important form of chemical energy in all cells.  All fuel sources of Nature, all foodstuffs of living things, produce ATP, which in turn powers virtually every activity of the cell and organism.  The cleavage of ATP is strongly exergonic. The energy

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ATP- The energy currency within the cell

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Q.- Adenosine triphosphate (ATP) is the energy currency within the cell. Which of the following best describes the type of compound ATP is? A. Phospholipid B. Amino acid C. Nucleotide D. Triacylglycerol E. Oligosaccharide. Details The correct answer is -C- Nucleotide. The nucleotide coenzyme adenosine triphosphate (ATP) is the most important form of chemical energy

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Case study- Porphyria

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A 30-year-old woman had severe abdominal pain, nausea, vomiting and diarrhea. Evaluations including upper and lower endoscopies did not establish any intestinal infection. She gradually improved and was discharged after 2 weeks. 2 years later she was admitted to a psychiatric unit with acute mental changes and hallucinations, she had to be transferred to the

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Case studies – Jaundice

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Case study-1 A 24 –year –old male suffering from Malaria was put on Primaquine. He developed malaise, fatigue and yellow discoloration of sclera and skin. On examination – There was pallor- ++, icterus ++, Pulse – 100/min., Temperature 102°F. The liver and spleen were palpable. The investigation report was as follows- Hb-5gm% TLC-13000 cmm esp. polymorphs

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Jaundice- An overview

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Bilirubin is the end product of heme degradation. From 70–90% of bilirubin is derived from degradation of the hemoglobin of senescent red blood cells. Bilirubin produced in the periphery is transported to the liver within the plasma, where, due to its insolubility in aqueous solutions, it is tightly bound to albumin. Under normal circumstances, bilirubin

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Case Study- Wilson’s Disease

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Case Details A 15 –year-old girl presented with abdominal pain and diarrhea for 3 days. She became jaundiced and a presumptive diagnosis of infective hepatitis was made, but serological tests were negative. She subsequently died of fulminant liver failure. At post-mortem, her liver copper concentration was found to be grossly increased. What is the probable diagnosis? What kind of

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