USMLE styled question bank

PDH complex and the TCA cycle- NBME style questions set-2

1. The cytosolic isoform of which of the following TCA cycle enzymes requires NADP⁺ as a coenzyme, which can be utilized in the reduced state for reductive biosynthesis? A. Aconitase B. Citrate Synthase C. Isocitrate Dehydrogenase D. Malate Dehydrogenase E. Succinate Dehydrogenase The correct answer is C: Isocitrate Dehydrogenase: The cytosolic isoform of isocitrate dehydrogenase […]

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PDH complex and the TCA cycle- NBME style questions set-1

1. A 24-year-old woman presents with diarrhea, dysphagia, jaundice, and white transverse lines on her fingernails (Mee’s lines). She is diagnosed with arsenic poisoning. Arsenic poisoning inhibits which of the following enzymes? A. Citrate synthase B. Isocitrate dehydrogenase C. Malate dehydrogenase D. Succinate dehydrogenase E. α-Keto glutarate dehydrogenase complex Correct answer: E. α-Keto glutarate dehydrogenase

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Glycolysis Review- NBME style questions with complete explanations

Q.1 Identify the Phosphoester that is predominantly encountered in erythrocytes and plays a vital role in modulating the oxygen-binding affinity of hemoglobin: A. 1,3-Bisphosphoglycerate B. 2,3-Bisphosphoglycerate C. Fructose 1,6-bisphosphate D. Fructose 6-phosphate E. Glucose 6-phosphate The correct answer is B. 2,3-Bisphosphoglycerate (2,3-BPG): 2,3-Bisphosphoglycerate is a negatively charged molecule found in high concentrations within erythrocytes. 2,3-BPG

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NBME-Style Case-Based Questions on the regulation of glycolysis with explanations

Question 1: A 25-year-old man runs a marathon. After 20 miles, his muscle cells are relying heavily on glycolysis for energy production. Which of the following changes is most likely increasing the rate of glycolysis in his muscles? A. Accumulation of alanine B. Decreased availability of glucose C. Decreased oxygen levels D. Increased AMP concentration

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Carbohydrate Metabolism – A Quick Revision with Multiple Choice Questions Covering All Pathways

Revise the essential concepts of carbohydrate metabolism with this comprehensive set of multiple-choice questions spanning all major pathways—glycolysis, gluconeogenesis, TCA cycle, glycogen metabolism, and the pentose phosphate pathway. Ideal for USMLE prep and biochemistry exams, this resource offers rapid revision with clear explanations for each answer.

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Amino Acid Metabolism- Set 2- Multiple-Choice Questions

Q.1 – A 12-year-old boy develops convulsions. After an Electroencephalogram (EEG), a neurologist determines that the child has epilepsy. He is started on benzodiazepine, which promotes the activity of GABA. GABA is derived from Glutamate by which of the following reactions?A) DeaminationB) DecarboxylationC) DehydrogenationD) HydroxylationE) TransaminationAnswer: B) DecarboxylationExplanation: GABA (gamma-aminobutyric acid) is synthesized from glutamate

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Amino acid Metabolism- Multiple-Choice Questions- Set 1

Test your understanding of amino acid metabolism with this high-yield multiple-choice question set designed for medical and health science students. Covering key pathways, clinical correlations, and enzyme functions, this Amino Acid MCQ Set 1 is perfect for USMLE, board exams, and biochemistry reviews. Each question includes a detailed explanation to support deep learning and exam readiness.

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Enzymology Revision (Multiple Choice Questions With Complete Explanations)

Q.1: Glycogen phosphorylase, which mobilizes glycogen for energy, requires which of the following as a cofactor? Adenosyl Cobalamine Coenzyme A Pyridoxal phosphate Tetrahydrofolate Thiamine pyrophosphate Correct Answer: C) Pyridoxal phosphate Explanation: Glycogen phosphorylase is instrumental in the process of glycogenolysis, where it facilitates the breakdown of glycogen into glucose-1-phosphate, thereby playing a vital role in

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Enzyme inhibition

A 54-year-old man complains of an acute onset of unilateral eye pain and a reduction in visual acuity. Conjunctival injection (eye redness) and a mild-dilated and non-reactive pupil are observed on physical examination. Fundoscopic examination reveals cupping of the optic disc. Recognizing the signs and symptoms of glaucoma, Acetazolamide is administered to decrease the production

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