Energy metabolism

Minor pathways of oxidation of fatty acids- Lecture-2 (omega and peroxisomal oxidation)

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Omega oxidation of fatty acids Another minor pathway for fatty acid oxidation also involves hydroxylation and occurs in the endoplasmic reticulum of many tissues. In this case, hydroxylation takes place on the methyl carbon at the other end of the molecule from the carboxyl group or on the carbon next to the methyl end. It […]

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Elevated Acyl carnitine compounds and associated hypoglycemia- What is the defect?

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Case details  A 5- year-old boy suffered gastroenteritis for two days and was brought to the emergency in a semiconscious state. Blood glucose at the time of admission was 45 mg/dl and his urine was negative for glucose and ketone bodies. Glucose was administered intravenously, and his condition improved within 10 minutes. Subsequent laboratory investigations

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Question the week-2 (Answer)

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A 65-year-old man with a history of type 2 diabetes mellitus is complaining of blurred vision and numbness in his toes. Laboratory results are significant for an increased BUN and creatinine, indicative of renal failure, and high HbA1c, indicative of chronic persistent hyperglycemia. Of the several proposed mechanisms, one mechanism responsible for hyperglycemia-induced complications in

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Summary- Regulation of Major Pathways Of Carbohydrate metabolism

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Enzyme Pathway Effect of Substrate Concentration Allosteric Modification/ Feedback Inhibition Induction/Repression Clinical Significance Hexokinase Glycolysis Feedback inhibition by Glucose-6-P – Deficiency causes Hemolytic anemia. Glucokinase Glycolysis Stimulated by a high carbohydrate diet   Activity decreases during fasting – Induced by Insulin Repressed by Glucagon Activity low in Diabetes Mellitus Phosphofructokinase-1 Glycolysis Stimulated by a high

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Hypoglycemia Due To Biotin deficiency

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A 32-year-old bodybuilder has decided to go on a diet consisting of egg whites to ensure only proteins for muscle growth. After a few weeks, he experiences decreased energy and is found to be hypoglycemic. A nutritionist tells the patient that he most likely has a deficiency of vitamin Biotin. Which of the following enzymes

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TCA Cycle- Multiple-choice questions

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1) A 24-year-old woman presents with diarrhea, dysphagia, jaundice, and white transverse lines on the fingernails (Mee’s lines). The patient is diagnosed with Arsenic poisoning, which inhibits which of the following enzymes? a) Citrate synthase b) Isocitrate dehydrogenase c) α-Keto glutarate dehydrogenase complex d) Succinate dehydrogenase e) Malate dehydrogenase 2) A biochemistry graduate student isolated

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Multiple-choice questions- Pentose phosphate pathway

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1) Glucose breakdown in certain mammalian and bacterial cells can occur by mechanisms other than classic glycolysis. In most of these, glucose 6-phosphate is oxidized to 6- 6-phosphogluconate, which is then further metabolized by: a) an aldolase-type split to form glyceric acid and glyceraldehyde 3-phosphate. b) an aldolase-type split to form glycolic acid and erythrose

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Gluconeogenesis- Multiple-choice questions

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1)  A 4-month-old boy is being evaluated for seizures, psychomotor retardation, and hypotonia. Workup reveals elevated serum levels of lactate, alanine, pyruvate, and keto acids. Based on the clinical presentation, pyruvate carboxylase activity is measured using fibroblasts from a skin biopsy and is found to be markedly decreased. This enzyme is normally used to directly

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Glycolysis- Multiple-choice questions (set-1)

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1). A patient has chronic obstructive pulmonary disease, and enough oxygen is not reaching her tissues.  All of the following are expected except- a) The electron transport chain would be inhibited b) Glycolysis would be activated by a low ATP/ADP ratio c) More than normal amounts of ATP would be synthesized. d) Concentrations of NADH and

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Biological oxidation and Electron transport chain (Multiple choice questions) – solved- part-3

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Q.1- Choose a site along the electron transport chain out of the following that is not coupled to ATP synthesis: a) NADH- coenzyme Q (CoQ) reductase b) Succinate-Co Q reductase c) Cytochrome bc1 reductase d) Cytochrome oxidase e) None of the above. Q.2- Choose a statement out of the following that best describes the uncouplers

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