The TCA cycle (Krebs cycle) serves as a central hub for both catabolic (energy-producing) and anabolic (biosynthetic) processes, making it a dual-purpose amphibolic pathway. Below is a table that summarizes the catabolic and anabolic roles of the TCA cycle, along with mnemonics to make these concepts easier to remember. Catabolic Role of the TCA Cycle: […]
Amphibolic Role of the TCA Cycle with Mnemonics Read More »
Hexokinase vs Glucokinase Regulation Feature Hexokinase Glucokinase Mnemonic Location Most tissues (muscle, brain) Liver and pancreatic β-cells “H in Human Tissues, G in Glucose Factories” Affinity for Glucose (Km) Low Km (high affinity) High Km (active only at high glucose) “Hexokinase is Hungry, Glucokinase is Greedy” Allosteric Inhibition Inhibited by Glucose-6-Phosphate No inhibition by Glucose-6-Phosphate
A Summary Of Regulation of Glycolysis, PDH Complex, and TCA Cycle (with mnemonics) Read More »
Site of Action Inhibitors / Uncouplers Mechanism Mnemonic for Easy Recall Complex I (NADH Dehydrogenase) Rotenone, Piericidin A, Amytal Blocks electron transfer from NADH to CoQ “Rotten Pies Available” (Rotenone, Piericidin A, Amytal block Complex I) Complex II (Succinate Dehydrogenase) Malonate, Carboxin, TTFA Competes with succinate, preventing electron transfer to CoQ “Malonate Causes Trouble Fast”
ETC Inhibitors, Uncouplers, and Transporter Inhibitors of Oxidative Phosphorylation Read More »
Glycolysis is the metabolic pathway that converts glucose into pyruvate, generating ATP and NADH in the process. It occurs in the cytoplasm of cells and is essential for energy production. Glycolysis is regulated at multiple levels to match energy demand with supply. Modes of Glycolysis Regulation Substrate Concentration The availability of glucose directly influences the
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🎧 Episode Summary: Welcome to Biochem Bytes, your go-to podcast for mastering core biochemistry topics in minutes. In today’s episode, we’re breaking down glycolysis—the central pathway of glucose metabolism. Glycolysis Simplified: Glycolysis is a 10-step metabolic pathway that occurs in the cytoplasm of all cells. It converts one molecule of glucose (a 6-carbon sugar) into
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Revise the essential concepts of carbohydrate metabolism with this comprehensive set of multiple-choice questions spanning all major pathways—glycolysis, gluconeogenesis, TCA cycle, glycogen metabolism, and the pentose phosphate pathway. Ideal for USMLE prep and biochemistry exams, this resource offers rapid revision with clear explanations for each answer.
Enzyme Pathway Effect of Substrate Concentration Allosteric Modification/ Feedback Inhibition Induction/Repression Clinical Significance Hexokinase Glycolysis Feedback inhibition by Glucose-6-P – Deficiency causes Hemolytic anemia. Glucokinase Glycolysis Stimulated by a high carbohydrate diet Activity decreases during fasting – Induced by Insulin Repressed by Glucagon Activity low in Diabetes Mellitus Phosphofructokinase-1 Glycolysis Stimulated by a high
Summary- Regulation of Major Pathways Of Carbohydrate metabolism Read More »
